High and low HDL cholesterol levels linked to dementia risk

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<root generator="drupal.xsl" gversion="1.7"> <header> <fileName>165485</fileName> <TBEID>0C04CAA9.SIG</TBEID> <TBUniqueIdentifier>MD_0C04CAA9</TBUniqueIdentifier> <newsOrJournal>News</newsOrJournal> <publisherName>Frontline Medical Communications</publisherName> <storyname/> <articleType>2</articleType> <TBLocation>QC Done-All Pubs</TBLocation> <QCDate>20231013T100026</QCDate> <firstPublished>20231013T141119</firstPublished> <LastPublished>20231013T141119</LastPublished> <pubStatus qcode="stat:"/> <embargoDate/> <killDate/> <CMSDate>20231013T141119</CMSDate> <articleSource/> <facebookInfo/> <meetingNumber/> <byline>Kelli Whitlock Burton</byline> <bylineText>KELLI WHITLOCK BURTON</bylineText> <bylineFull>KELLI WHITLOCK BURTON</bylineFull> <bylineTitleText/> <USOrGlobal/> <wireDocType/> <newsDocType/> <journalDocType/> <linkLabel/> <pageRange/> <citation/> <quizID/> <indexIssueDate/> <itemClass qcode="ninat:text"/> <provider qcode="provider:imng"> <name>IMNG Medical Media</name> <rightsInfo> <copyrightHolder> <name>Frontline Medical News</name> </copyrightHolder> <copyrightNotice>Copyright (c) 2015 Frontline Medical News, a Frontline Medical Communications Inc. company. All rights reserved. This material may not be published, broadcast, copied, or otherwise reproduced or distributed without the prior written permission of Frontline Medical Communications Inc.</copyrightNotice> </rightsInfo> </provider> <abstract/> <metaDescription>High and low levels of HDL cholesterol but not levels of LDL cholesterol are associated with an increased risk for dementia in older adults, a new study found.</metaDescription> <articlePDF/> <teaserImage/> <teaser>There was no significant association between LDL cholesterol and dementia risk.</teaser> <title>High and low HDL cholesterol levels linked to dementia risk</title> <deck/> <disclaimer/> <AuthorList/> <articleURL/> <doi/> <pubMedID/> <publishXMLStatus/> <publishXMLVersion>1</publishXMLVersion> <useEISSN>0</useEISSN> <urgency/> <pubPubdateYear/> <pubPubdateMonth/> <pubPubdateDay/> <pubVolume/> <pubNumber/> <wireChannels/> <primaryCMSID/> <CMSIDs/> <keywords/> <seeAlsos/> <publications_g> <publicationData> <publicationCode>fp</publicationCode> <pubIssueName/> <pubArticleType/> <pubTopics/> <pubCategories/> <pubSections/> </publicationData> <publicationData> <publicationCode>im</publicationCode> <pubIssueName/> <pubArticleType/> <pubTopics/> <pubCategories/> <pubSections/> </publicationData> <publicationData> <publicationCode>nr</publicationCode> <pubIssueName/> <pubArticleType/> <pubTopics/> <pubCategories/> <pubSections/> <journalTitle>Neurology Reviews</journalTitle> <journalFullTitle>Neurology Reviews</journalFullTitle> <copyrightStatement>2018 Frontline Medical Communications Inc.,</copyrightStatement> </publicationData> <publicationData> <publicationCode>card</publicationCode> <pubIssueName/> <pubArticleType/> <pubTopics/> <pubCategories/> <pubSections/> </publicationData> </publications_g> <publications> <term>15</term> <term canonical="true">21</term> <term>22</term> <term>5</term> </publications> <sections> <term>27970</term> <term canonical="true">39313</term> </sections> <topics> <term canonical="true">258</term> <term>194</term> <term>239</term> <term>180</term> </topics> <links/> </header> <itemSet> <newsItem> <itemMeta> <itemRole>Main</itemRole> <itemClass>text</itemClass> <title>High and low HDL cholesterol levels linked to dementia risk</title> <deck/> </itemMeta> <itemContent> <h2>TOPLINE:</h2> <p>High and low levels of HDL cholesterol but not levels of LDL cholesterol are associated with an increased risk for dementia in older adults, a new study found.</p> <h2>METHODOLOGY:</h2> <ul class="body"> <li>Electronic health record and survey data on 184,367 Kaiser Permanente Northern California participants (median age, 69.5 years) with no history of dementia were taken.</li> <li>Cholesterol levels were measured within 2 years of survey completion.</li> </ul> <h2>TAKEAWAY:</h2> <ul class="body"> <li>There were 25,214 incident cases of dementia reported over an average follow-up of 8.77 years.</li> <li>Dementia risk was significantly higher in people with low HDL cholesterol (11-41 mg/dL; adjusted hazard ratio, 1.07; 95% confidence interval, 1.03-1.11) and high HDL cholesterol (&gt; 65 mg/dL; aHR, 1.15; 95% CI, 1.11-1.20).</li> <li>The study demonstrates an association between low and high levels of “good” cholesterol but not a causal link.</li> <li>There was no significant association between LDL cholesterol and dementia risk.</li> </ul> <h2>IN PRACTICE:</h2> <p>“These results support the conclusion that some lipoproteins may be modifiable risk factors for dementia, even in late life,” the authors wrote.</p> <h2>SOURCE:</h2> <p>The study was conducted by Erin L. Ferguson, MPH, department of epidemiology &amp; biostatistics, University of California, San Francisco, and was funded by the National Institutes of Health. It was <a href="https://n.neurology.org/content/early/2023/10/04/WNL.0000000000207876">published online</a> in Neurology.</p> <h2>LIMITATIONS:</h2> <p>There were no adjustments for apo E status and confounding and selection bias.</p> <h2>DISCLOSURES:</h2> <p>The authors report no relevant disclosures.<span class="end"/></p> <p> <em>A version of this article first appeared on <span class="Hyperlink"><a href="https://www.medscape.com/viewarticle/997326">Medscape.com</a></span>.</em> </p> </itemContent> </newsItem> <newsItem> <itemMeta> <itemRole>teaser</itemRole> <itemClass>text</itemClass> <title/> <deck/> </itemMeta> <itemContent> </itemContent> </newsItem> </itemSet></root>